In any case, I would suppose a good purpose to supplement w/zinc at bedtime would be if you're also taking B-6 and magnesium aka ZMA. Iron, magnesium and fish oil supplements are the most common culprits for digestive upset when taken on an empty stomach, so take extra care to have these with a meal or snack. Skip the stomach ache by taking them with food, using easy-to-digest formats and reducing your dose size. I always see labels suggesting use of ZMA on an empty stomach. Deficiencies and Excesses Since fruits and grains are not optimal sources of zinc, vegans and vegetarians can be deficient in zinc as vegetables. Zinc deficiency in the elderly may be related to ulcers, dermatitis, hair … Chelating agents are chemical compounds that bond with metal ions (such as zinc… ... my retina of zinc which the eye needed — the chelation effect. Taking vitamins on an empty stomach can make you feel sick. Some people experience nausea when taking NAC on an empty stomach, but the majority of people do not experience any side effects if they take it with food. Phytic acid found in legumes will also block zinc and other mineral absorption. Take zinc in the morning just before breakfast and then take magnesium at night before sleeping to help with muscle soreness and recovery. I just make sure I haven't eaten anything in about an 1-1.5 hrs (max) when I take a supplement that is suggested to be taken on an empty stomach. If most of your meals are rich in fruits and vegetables (like they should be!) High doses above the recommended amounts might cause fever, coughing, stomach pain, fatigue, and many other problems. ReddIt. When it comes to optimizing digestive health (and general health for that matter), zinc has long been thought of as a key piece of the puzzle. She took it 2 hours after her last meal, apparently you have to take this stuff on an empty stomach. Magnesium is best taken at night before sleep as it relaxes the muscles. Zinc should be taken on an empty stomach last thing at night. Taking high amounts of zinc is LIKELY UNSAFE. Email. Zinc and magnesium are best absorbed on an empty stomach, but if it messes with your stomach have it with some food. 10 mg/d of zinc on an empty stomach is sufficient to prevent or reverse a deficiency, but this should be doubled in an acute crisis of diarrhea or with chronic intestinal malabsorption. She started drinking a half teaspoon then worked up to a tablespoon of diatomaceous earth every night. your best bet may be to take zinc on an empty stomach before breakfast or shortly before bed. Taking more than 100 mg of supplemental zinc daily or taking supplemental zinc for 10 or more years doubles the risk of developing prostate cancer. If you eat a lot of zinc-rich foods and do not have any signs of zinc deficiency, you probably don't need a supplement . What she told me next blew me away. 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